Publications

Please find below a list of current publications relating to the Head & Neck 5000 study.  Further publications are in progress; please revisit the website for updates.

 

 

2021

 

Chen H, Majumdar A, Wang L, et. al. Large-scale cross-cancer fine-mapping of the  5p15.33 region reveals multiple independent signals  Human Genetics and Genomics Advances 2021 Epub June12, doi: https://doi.org/10.1016/j.xhgg.2021.100041

 

Ferreiro-Iglesias A, McKay J, Brenner N, et al. Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer Nat Commun 2021 12, 5945. https://doi.org/10.1038/s41467-021-26151-9

 

Gormley M, Yarmolinsky J, Dudding T et. al.  Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.  PLoS Genet. 2021 Apr 22;17(4):e1009525. doi: 10.1371/journal.pgen.1009525. eCollection 2021 Apr.PMID: 33886544 

 

Ingarfield K, McMahon A, Hurley K, Toms S, Pring M, Thomas S, Waylen A, Pawlita M, Waterboer T, Ness A, Conway D  Inequality in survival of people with head and neck cancer: Head and Neck 5000 cohort study  Head and Neck  2021 Apr;43(4):1252-1270. doi: 10.1002/hed.26589. Epub 2021 Jan 8

 

Lesseur C, Ferreiro-Iglesias A, McKay JD, et al.  Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers  PLoS Genetics. 2021 Mar 5;17(3):e1009254. doi: 10.1371/journal.pgen. 1009254. eCollection 2021 Mar.PLoS Genet. 2021. PMID: 33667223 

 

O'Hara J, Whitmarsh A, Pring M, Thomas S, Ness A. Quality of life following treatment for T1a glottic cancer with surgery or radiotherapy: outcomes from the Head and Neck 5000 cohort. Clin Otolaryngol. 2021 Aug 15. doi: 10.1111/coa.13849. Online ahead of print. PMID: 34392607

 

Patterson J, Lu L, Watson L, Harding S, Ness R, Thomas S, Waylen A, Waterboer T, Sharp L.   Trends in, and predictors of, swallowing and social eating outcomes in head and neck cancer survivors: A longitudinal analysis of head and neck 5000   Oral Oncology  2021 Jul; 118:105344  

 

Patterson J M, Lu L, Watson L, et. al. Associations between markers of social functioning and depression and quality of life in survivors of head and neck cancer: Findings from the Head and Neck Cancer 5000 study.  Psycho-Oncology 2021 Epub September 30 https://doi.org/10.1002/pon.5830

 

Whitmarsh A, Pring M, Thomas SJ, Waylen A, Ness AR, Dudding T, Pawlita M, Brenner N, Waterboer T, Schroeder L. Survival advantage in patients with human papillomavirus-driven oropharyngeal cancer and variation by demographic characteristics and serologic response: Findings from Head and Neck 5000. Cancer. 2021 Jul 15;127(14):2442-2452. doi: 10.1002/cncr.33505. Epub 2021 Mar 15.

 

 

 

2020

 

Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, Ness AR, Brennan P, Munafò M, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Davey Smith G, Richmond RC  A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer.  Nat Commun. 2020 Nov 27;11(1):6071. doi: 10.1038/s41467-020-19822-6.

 

Howe LJ, Hemani, G, Lesseur C, Gaborieau V, Ludwig, KU, Mangold E, Brennan P, Ness AR, St Pourcain B, Davey Smith G, Lewis SJ Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms. Genetic Epidemiology  2020 Nov;44(8):924-933. doi: 10.1002/gepi.22343. Epub 2020 Jul 24.

 

Karsten RT, van den Brekel MWM, Smeele LE, Navran A, Leary S, Ingarfield K, Pawlita M, Waterboer T, Thomas SJ, Ness AR.  Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study. Head Neck 2020 Aug;42(8):1981-1993. doi: 10.1002/hed.26131. Epub 2020 Mar 6.

 

Langdon R, Richmond R, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Gaunt T, Smith GD, Suderman M, Thomas S, Ness A, Relton C.

Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clin Epigenetics. 2020 Jun 29;12(1):95.

 

Langdon RJ, Beynon RA, Ingarfield K, Marioni RE, McCartney DL, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer Clin Epigenetics. 2020 Apr 22;12(1):58.

 

Mayland CR, Ingarfield K, Rogers SN, Dey P, Thomas S, Waylen A, Leary SD, Pring M, Hurley K, Waterboer T, Pawlita M, Ness AR.   Disease trajectories, place and mode of death in people with head and neck cancer: Findings from the 'Head and Neck 5000' population-based prospective clinical cohort studyPalliat Med. 2020 May;34(5):639-650.  doi:10.1177/0269216320904313. Epub 2020 Feb 27.

 

Rogers SN, Waylen AE, Thomas S, Penfold C, Pring M, Waterboer T, Pawlita M, Hurley K, Ness AR.

Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study. Eur Arch Otorhinolaryngol. 2020 May;277(5):1515-1523  doi: 10.1007/s00405-020-05850-x. Epub 2020 Feb 15.

 

Schroeder L, Pring M, Ingarfield K, Pawlita M, Leary S, Thomas SJ, Waylen A, Waterboer T, Ness AR.

HPV driven squamous cell head and neck cancer of unknown primary is likely to be HPV driven squamous cell oropharyngeal cancer Oral Oncology 2020 Aug;107:104721

 

Simon J, Schroeder L, Ingarfield K, Diehl S, Werner J, Brenner N, Liu Z, Pawlita M, Pring M, Butt J, Ness A, Waterboer T. Epstein-Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country. Int J Cancer. 2020 Apr 12. doi: 10.1002/ijc.33006. Epub 2020 April 24

 

 

2019

 

Dale OT, Pring M, Davies A, Leary S, Ingarfield K, Toms S, Waterboer T, Pawlita M, Ness AR, Thomas SJ. Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study. Clinical Otolaryngology. 2019 Nov;44(6):961-967

 

Davies A, Waylen A, Leary S, Thomas SJ, Pring M, Janssen B, Beynon R, Lang S, Schimansky S, Hurley K, Ness AR.  Assessing the validity of EQ-5D-5L in people with head & neck cancer: Does a generic quality of life measure perform as well as a disease-specific measure in a patient population? Oral Oncology 2020 Feb;101:104504. doi: 10.1016/j.oraloncology.2019.104504. Epub 2019 Dec 10.

 

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP. et al. Shared heritability and functional enrichment across six solid cancersNat Commun. 2019 Jan 25;10(1):431.

 

Kachuri L. Saarele O. Bojesen S. et al Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers Int J Epidemiol 2019 Jun 1;48(3):751-766 doi: 10.1093/ije/dyy140.

 

Lang S, Schimansky S, Beynon R, Penfold C, Davies A, Waylen A, Thomas SJ, Pring M, Pawlita M, Waterboer T, Ness AR. Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000. Head Neck. 2019 Jul;41(7):2074-2084

 

Yousefi PD, Richmond R, Langdon R, Ness AR, Liu C, Levy D, Relton C, Suderman M, Zuccolo L. Validation and characterisation of a DNA methylation alcohol biomarker across the life course. Clin Epigenetics. 2019 Nov 27;11(1):163.

 

 

2018

 

Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SM, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas SJ, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncol 2018; 85: 87-94.

 

Beynon RA, Lang S, Schimansky S, Penfold CM, Waylen A, Thomas SJ, Pawlita M, Waterboer T T, Martin RM, May M, Ness AR. Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all-cause mortality: Results from Head and Neck 5000, a prospective observational cohort of people with head and neck cancer. Int J Cancer 2018; 143: 1114-1127.

 

Dudding T, Johansson M, Thomas SJ, Brennan P, Martin RM, Timpson NJ. Assessing the causal association between

25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization Int J Cancer 2018; 143: 1029-1036. 

 

Jansen F, Verdonck-de Leeuw IM, Cuijpers P, Leemans CR, Waterboer T, Pawlita M, Penfold C, Thomas SJ, Waylen A, Ness AR. Depressive symptoms in relation to overall survival in people with head and neck cancer: a longitudinal cohort study. Psychooncology 2018; 27: 2245-2256. 

 

Penfold CM, Thomas SJ, Waylen A, Ness AR. Change in alcohol and tobacco consumption after a diagnosis of head and neck cancer: Findings from Head and Neck 5000. Head Neck 2018; 40: 1389-1399.

 

Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A, Thomas SJ, Pring M, Pawlita M, Waterboer T, Ness AR. Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Head Neck. 2019 Apr;41(4):1053-1062

 

Thomas SJ, Penfold CM, Waylen A, Ness AR. The changing aetiology of head and neck squamous cell cancer: a tale of three cancers? Clin Otolaryngol 2018; 10.1111/coa.13144

 

 

2016

 

Lesseur C, Diergaarde B, Olshan AF, Wunsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Nato J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesei J, Kjaerheim K, Zaridze D, Johansson M, Weissler MC, Tajara EH, Nunes FD, de carvalho MB, Thomas SJ, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P.  Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

Nature Genetics 2016: 48: 1544-1550

 

 

2015

 

Ness AR, Waylen A, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W
Worthington H, Nutting C, Fisher SO, Rogers SN, Thomas SJ, Head & Neck Study Team. Recruitment response rates and characteristics of 5511 enrolled in a perspective clinical cohort study head & neck 5000. Clinical Otolaryngology 2015; 41: 804-809.

 

 

2014

 

Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ, Head & Neck 5000 Study Team.   Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource : head and neck 5000. BMC Cancer 2014; 14: 973

 

 

2012

 

Hughes C, Homer J, Bradley P, Nutting C, Ness AR, Persson M, Jefferys M, Waylen, A, Leary S, Thomas SJ.

An evaluation of current services available for people diagnosed with Head and Neck Cancer in the UK (2009-2010). Clin Oncol 2012; 24: e187-92.