Please find below a list of current publications relating to the Head & Neck 5000 study.  Further publications are in progress; please revisit the website for updates.





Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SM, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncol 2018; 85: 87-94.


Beynon RA, Lang S, Schimansky S, Penfold CM, Waylen A, Thomas SJ, Pawlita M, Waterboer T T, Martin RM, May M, Ness AR. Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all-cause mortality: Results from Head and Neck 5000, a prospective observational cohort of people with head and neck cancer. Int J Cancer 2018; 143: 1114-1127.


Dudding T, Johansson M, Thomas SJ, Brennan P, Martin RM, Timpson NJ. Assessing the causal association between

25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization Int J Cancer 2018 143: 1029-1036. 


Jansen F, Verdonck-de Leeuw IM, Cuijpers P, Leemans CR, Waterboer T, Pawlita M, Penfold C, Thomas SJ, Waylen A, Ness AR. Depressive symptoms in relation to overall survival in people with head and neck cancer: a longitudinal cohort study. Psychooncology 2018; 27: 2245-2256. 


Kachuri L. Saarele O. Bojesen S. et al Mendelian Randomization and mediation analysis of leukocyte telomere length

and risk of lung and head and neck cancers  Int J Epidemiol 2018 [Epub ahead of print]


Penfold CM, Thomas SJ, Waylen A, Ness AR. Change in alcohol and tobacco consumption after a diagnosis of head and neck cancer: Findings from Head and Neck 5000. Head Neck 2018; 40: 1389-1399.


Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A, Thomas S, Pring M, Pawlita M, Waterboer T, Ness A

Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Head Neck. 2018; doi: 10.1002/hed.25543. [Epub ahead of print]


Thomas SJ, Penfold CM, Waylen A, Ness AR. The changing aetiology of head and neck squamous cell cancer: a tale of three cancers? Clin Otolaryngol 2018 [Epub ahead of print]





Lesseur C, Diergaarde B, Olshan AF, Wunsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Nato J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesei J, Kjaerheim K, Zaridze D, Johansson M, Weissler MC, Tajara EH, Nunes FD, de carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P.  Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

Nature Genetics 2016: 48: 1544-1550





Ness AR, Waylen A, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W
Worthington H, Nutting C, Fisher SO, Rogers SN, Thomas SJ; Head & Neck Study Team. Recruitment response rates and characteristics of 5511 enrolled in a perspective clinical cohort study head & neck 5000. Clinical Otolaryngology 2015; 41: 804-809.





Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ, Head & Neck 5000 Study Team.   Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource : head and neck 5000. BMC Cancer 2014; 14973





Hughes C, Homer J, Bradley P, Nutting C, Ness A, Persson M, Jefferys M,Waylen, A, Leary S, Thomas S. An evaluation of current services available for people diagnosed with Head and Neck Cancer in the UK (2009-2010). Clin Oncol 2012; 24: e187-92.