Publications
Please find below a list of current publications relating to the Head & Neck 5000 study. Further publications are in progress; please revisit the website for updates.
2024
Bolnykh I, Patterson J, Harding S, et.al. Cancer-related pain in head and neck cancer survivors: longitudinal findings from the Head and Neck 5000 clinical cohort. J Cancer Surviv. 2024 Feb 29. doi: 10.1007/s11764-024-01554-x. Online ahead of print.
Tasoulas J, Farquhar JD, Sheth S, et. al. Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis. J Natl Cancer Inst 2024 Jan; 116(1): 105–114 Published online 2023 Sep 19. doi: 10.1093/jnci/djad156
2023
Budhathoki S, Diergaarde B, Liu G, et. al. A risk prediction model for head and neck cancers incorporating lifestyle factors, HPV serology and genetic markers. Int J Cancer 2023 Jan 24 doi: 10.1002/ijc.34444. Online ahead of print
Gormley M, Dudding T, Thomas SJ, et.al. Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization. eLife 2023 April 12 doi: 10.7554/eLife.82674
Kusters JMA, Diergaarde B, Ness A, et. al. Diagnostic Accuracy of HPV16 Early Antigen Serology For HPV-Driven Oropharyngeal Cancer is Independent of Age and Sex Int J Cancer 2023 Sep 11. doi: 10.1002/ijc.34710. Online ahead of print
Schieber J, Pring M, Ness A, et. al. Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients. Cancers (Basel) 2023 May 15(9) 2578. doi: 10.3390/cancers15092578
Sharp L, Watson L-J, Lu L, et. al. Cancer-related fatigue in head and neck cancer survivors: longitudinal findings from the Head and Neck 5000 prospective clinical cohort. Cancers 2023 Oct 5;15(19):4864. doi: 10.3390/cancers15194864
2022
Beynon R, Ingle S, Langdon R, et. al. Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer Clinical Epigenetics 2022 Jan 3;14(1):1. doi: 10.1186/s13148-021-01220-4.
Gormley M, Dudding T, Kachuri L, et. al. Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization BMC Medicine epub 2022 Jan 31 doi.org/10.1186/s12916-022-02233-3
Gormley M, Gray E, Richards C, et. al. An update on oral cavity cancer: epidemiological trends, prevention strategies and novel approaches in diagnosis and prognosis Community Dental Health 2022 Aug 30;39(3):197-205. doi: 10.1922/CDH_00032Gormley09
Naderi E, Schack LMH, Welsh C, et. al. Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer. Radiother Oncol. 2022 176:138-148 doi: 10.1016/j.radonc.2022.09.016. Epub 2022 Sep 30
2021
Chen H, Majumdar A, Wang L, et. al. Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals Human Genetics and Genomics Advances 2021 Jul 8;2(3):100041. doi: 10.1016/j.xhgg.2021.100041. Epub 2021 Jun 12.
Ferreiro-Iglesias A, McKay J, Brenner N, et al. Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer Nat Commun 2021 Oct 12;12(1):5945. doi: 10.1038/s41467-021-26151-9.
Gormley M, Yarmolinsky J, Dudding T, et, al. Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study. PLoS Genet. 2021 Apr 22;17(4):e1009525. doi: 10.1371/journal.pgen.1009525
Ingarfield K, McMahon A, Hurley K, Toms S, Pring M, Thomas S, Waylen A, Pawlita M, Waterboer T, Ness A, Conway D Inequality in survival of people with head and neck cancer: Head and Neck 5000 cohort study Head and Neck 2021 Apr;43(4):1252-1270. doi: 10.1002/hed.26589. Epub 2021 Jan 8.
Lesseur C, Ferreiro-Iglesias A, McKay JD, et al. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers PLoS Genet 2021 Mar 5;17(3):e1009254. doi: 10.1371/journal.pgen.1009254. eCollection 2021 Mar.
O'Hara J, Whitmarsh A, Pring M, Thomas S, Ness A. Quality of life following treatment for T1a glottic cancer with surgery or radiotherapy: outcomes from the Head and Neck 5000 cohort Clin Otolaryngol. 2021 Aug 15. doi: 10.1111/coa.13849. Online ahead of print. PMID: 34392607
Patterson J, Lu L, Watson L, Harding S, Ness R, Thomas S, Waylen A, Waterboer T, Sharp L. Trends in, and predictors of, swallowing and social eating outcomes in head and neck cancer survivors: A longitudinal analysis of head and neck 5000 Oral Oncol. 2021 Jul;118:105344. doi: 10.1016/j.oraloncology.2021.105344. Epub 2021 May 20.
Patterson J M, Lu L, Watson L, et. al. Associations between markers of social functioning and depression and quality of life in survivors of head and neck cancer: Findings from the Head and Neck Cancer 5000 study. Psycho-Oncology. 2021 Sep 30. doi: 10.1002/pon.5830. Epub September 30.
Whitmarsh A, Pring M, Thomas SJ, Waylen A, Ness AR, Dudding T, Pawlita M, Brenner N, Waterboer T, Schroeder L. Survival advantage in patients with human papillomavirus-driven oropharyngeal cancer and variation by demographic characteristics and serologic response: Findings from Head and Neck 5000 Cancer. 2021 Jul 15;127(14):2442-2452. doi: 10.1002/cncr.33505. Epub 2021 Mar 15.
2020
Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, Ness AR, Brennan P, Munafò M, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Davey Smith G, Richmond RC A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nat Commun. 2020 Nov 27;11(1):6071. doi: 10.1038/s41467-020-19822-6.
Howe LJ, Hemani, G, Lesseur C, Gaborieau V, Ludwig, KU, Mangold E, Brennan P, Ness AR, St Pourcain B, Davey Smith G, Lewis SJ Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms. Genetic Epidemiology 2020 Nov;44(8):924-933. doi: 10.1002/gepi.22343. Epub 2020 Jul 24.
Karsten RT, van den Brekel MWM, Smeele LE, Navran A, Leary S, Ingarfield K, Pawlita M, Waterboer T, Thomas SJ, Ness AR. Patient-reported swallowing function after treatment for early-stage oropharyngeal carcinoma: Population-based study. Head Neck 2020 Aug;42(8):1981-1993. doi: 10.1002/hed.26131. Epub 2020 Mar 6.
Langdon R, Richmond R, Elliott HR, Dudding T, Kazmi N, Penfold C, Ingarfield K, Ho K, Bretherick A, Haley C, Zeng Y, Walker RM, Pawlita M, Waterboer T, Gaunt T, Smith GD, Suderman M, Thomas S, Ness A, Relton C.
Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer. Clin Epigenetics. 2020 Jun 29;12(1):95.
Langdon RJ, Beynon RA, Ingarfield K, Marioni RE, McCartney DL, Martin RM, Ness AR, Pawlita M, Waterboer T, Relton C, Thomas SJ, Richmond RC Epigenetic prediction of complex traits and mortality in a cohort of individuals with oropharyngeal cancer Clin Epigenetics. 2020 Apr 22;12(1):58.
Mayland CR, Ingarfield K, Rogers SN, Dey P, Thomas S, Waylen A, Leary SD, Pring M, Hurley K, Waterboer T, Pawlita M, Ness AR. Disease trajectories, place and mode of death in people with head and neck cancer: Findings from the 'Head and Neck 5000' population-based prospective clinical cohort study. Palliat Med. 2020 May;34(5):639-650. doi:10.1177/0269216320904313. Epub 2020 Feb 27.
Rogers SN, Waylen AE, Thomas S, Penfold C, Pring M, Waterboer T, Pawlita M, Hurley K, Ness AR.
Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study. Eur Arch Otorhinolaryngol. 2020 May;277(5):1515-1523 doi: 10.1007/s00405-020-05850-x. Epub 2020 Feb 15.
Schroeder L, Pring M, Ingarfield K, Pawlita M, Leary S, Thomas SJ, Waylen A, Waterboer T, Ness AR.
HPV driven squamous cell head and neck cancer of unknown primary is likely to be HPV driven squamous cell oropharyngeal cancer Oral Oncology 2020 Aug;107:104721
Simon J, Schroeder L, Ingarfield K, Diehl S, Werner J, Brenner N, Liu Z, Pawlita M, Pring M, Butt J, Ness A, Waterboer T. Epstein-Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country. Int J Cancer. 2020 Apr 12. doi: 10.1002/ijc.33006. Epub 2020 April 24
2019
Dale OT, Pring M, Davies A, Leary S, Ingarfield K, Toms S, Waterboer T, Pawlita M, Ness AR, Thomas SJ. Squamous cell carcinoma of the nasal cavity: A descriptive analysis of cases from the Head and Neck 5000 study. Clinical Otolaryngology. 2019 Nov;44(6):961-967
Davies A, Waylen A, Leary S, Thomas SJ, Pring M, Janssen B, Beynon R, Lang S, Schimansky S, Hurley K, Ness AR. Assessing the validity of EQ-5D-5L in people with head & neck cancer: Does a generic quality of life measure perform as well as a disease-specific measure in a patient population? Oral Oncology 2020 Feb;101:104504. doi: 10.1016/j.oraloncology.2019.104504. Epub 2019 Dec 10.
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP. et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 Jan 25;10(1):431.
Kachuri L. Saarele O. Bojesen S. et al Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers Int J Epidemiol 2019 Jun 1;48(3):751-766 doi: 10.1093/ije/dyy140.
Lang S, Schimansky S, Beynon R, Penfold C, Davies A, Waylen A, Thomas SJ, Pring M, Pawlita M, Waterboer T, Ness AR. Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000. Head Neck. 2019 Jul;41(7):2074-2084
Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A, Thomas SJ, Pring M, Pawlita M, Waterboer T, Ness AR. Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000
Head Neck. 2019 Apr;41(4):1053-1062
Yousefi PD, Richmond R, Langdon R, Ness AR, Liu C, Levy D, Relton C, Suderman M, Zuccolo L. Validation and characterisation of a DNA methylation alcohol biomarker across the life course. Clin Epigenetics. 2019 Nov 27;11(1):163.
2018
Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SM, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas SJ, Ness AR, Relton CL. DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival. Oral Oncol 2018; 85: 87-94.
Beynon RA, Lang S, Schimansky S, Penfold CM, Waylen A, Thomas SJ, Pawlita M, Waterboer T T, Martin RM, May M, Ness AR. Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all-cause mortality: Results from Head and Neck 5000, a prospective observational cohort of people with head and neck cancer. Int J Cancer 2018; 143: 1114-1127.
Dudding T, Johansson M, Thomas SJ, Brennan P, Martin RM, Timpson NJ. Assessing the causal association between
25-hydroxyvitamin D and the risk of oral and oropharyngeal cancer using Mendelian randomization Int J Cancer 2018; 143: 1029-1036.
Jansen F, Verdonck-de Leeuw IM, Cuijpers P, Leemans CR, Waterboer T, Pawlita M, Penfold C, Thomas SJ, Waylen A, Ness AR. Depressive symptoms in relation to overall survival in people with head and neck cancer: a longitudinal cohort study. Psychooncology 2018; 27: 2245-2256.
Penfold CM, Thomas SJ, Waylen A, Ness AR. Change in alcohol and tobacco consumption after a diagnosis of head and neck cancer: Findings from Head and Neck 5000. Head Neck 2018; 40: 1389-1399.
Thomas SJ, Penfold CM, Waylen A, Ness AR. The changing aetiology of head and neck squamous cell cancer: a tale of three cancers? Clin Otolaryngol 2018; 10.1111/coa.13144
2016
Lesseur C, Diergaarde B, Olshan AF, Wunsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Nato J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesei J, Kjaerheim K, Zaridze D, Johansson M, Weissler MC, Tajara EH, Nunes FD, de carvalho MB, Thomas SJ, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Nature Genetics 2016: 48: 1544-1550
2015
Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary SD, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ, Head & Neck Study Team. Recruitment response rates and characteristics of 5511 enrolled in a perspective clinical cohort study head & neck 5000. Clinical Otolaryngology 2015; 41: 804-809.
2014
Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ, Head & Neck 5000 Study Team. Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource : head and neck 5000. BMC Cancer 2014; 14: 973
2012
Hughes C, Homer J, Bradley P, Nutting C, Ness AR, Persson M, Jefferys M, Waylen, A, Leary S, Thomas SJ.
An evaluation of current services available for people diagnosed with Head and Neck Cancer in the UK (2009-2010). Clin Oncol 2012; 24: e187-92.
